Glycyrrhizin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

作用 甘草（甘草）甜根中的生物活性成分。抗病毒物质。

Actions Biologically active constituent in the sweet root of Glycyrrhiza species (licorice). Antiviral. Packaging 25,100 g in poly bottle(In Vitro):Glycyrrhizic acid shows a series of anti-cancer-related pharmacological activities, such as broad-spectrum anti-cancer ability, resistance to the tissue toxicity caused by chemotherapy and radiation, drug absorption enhancing effects and anti-multidrug resistance (MDR) mechanisms, as a carrier material in drug delivery systems.In intestinal NCI-H716 cells that secretes GLP-1, Glycyrrhizic acid promotes GLP-1 secretion with a marked elevation of calcium levels. Glycyrrhizic acid can enhance GLP-1 secretion through TGR5 activation.Glycyrrhizic acid can form a stable transparent low-molecular-weight hydrogels (LMWHs) at 37°C in physiological phosphate buffered saline (PBS) with nanoclusters as the microstructures.(In Vivo):In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), Glycyrrhizic acid increases the level of plasma GLP-1, which is blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-coupled receptor 5 (TGR5). Glycyrrhizic acid (Glycyrrhizic acid; 50 mg/kg, i.p.) significantly decreases the levels of TgAb, HMGB1, TNF-α, IL-6, IL-1β in mice.

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Glycyrrhizic Acid

Metabolic Enzyme/Protease

Dehydrogenase

Dehydrogenase

Inflammation/Immunology

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1405-86-3

822.93

C42H62O16

>98% (HPLC)

Ethanol: 165 mg/mL (200.5 mM); Water: 20 mg/mL (24.3 mM); DMSO: 117 mg/mL (142.17 mM)

O[C@@H]([C@@H]([C@@H](C(O)=O)O1)O)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O2)O)O)O)[C@H]1O[C@@H](C(C)([C@](CC[C@@]([C@@]3(CC[C@]4(CC[C@](C[C@]4(C3=C5)[H])(C(O)=O)C)C)C)6C)7[H])C)CC[C@]7(C)[C@@]6([H])C5=O

(2S,3S,4S,5R,6R)-6-(((2S,3R,4S,5S,6S)-6-carboxy-2-(((3R,4aR,6aR,6bS,8aS,11R,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years