Glycyrrhizin ( Glycyrrhizic Acid )

产品货号. M11702 CAS No. 1405-86-3

作用甘草（甘草）甜根中的生物活性成分。抗病毒物质。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	￥235	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Glycyrrhizin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

作用甘草（甘草）甜根中的生物活性成分。抗病毒物质。
产品描述

Actions Biologically active constituent in the sweet root of Glycyrrhiza species (licorice). Antiviral. Packaging 25,100 g in poly bottle(In Vitro):Glycyrrhizic acid shows a series of anti-cancer-related pharmacological activities, such as broad-spectrum anti-cancer ability, resistance to the tissue toxicity caused by chemotherapy and radiation, drug absorption enhancing effects and anti-multidrug resistance (MDR) mechanisms, as a carrier material in drug delivery systems.In intestinal NCI-H716 cells that secretes GLP-1, Glycyrrhizic acid promotes GLP-1 secretion with a marked elevation of calcium levels. Glycyrrhizic acid can enhance GLP-1 secretion through TGR5 activation.Glycyrrhizic acid can form a stable transparent low-molecular-weight hydrogels (LMWHs) at 37°C in physiological phosphate buffered saline (PBS) with nanoclusters as the microstructures.(In Vivo):In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), Glycyrrhizic acid increases the level of plasma GLP-1, which is blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-coupled receptor 5 (TGR5). Glycyrrhizic acid (Glycyrrhizic acid; 50 mg/kg, i.p.) significantly decreases the levels of TgAb, HMGB1, TNF-α, IL-6, IL-1β in mice.
体外实验

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体内实验

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同义词

Glycyrrhizic Acid
通路

Metabolic Enzyme/Protease
靶点

Dehydrogenase
受体

Dehydrogenase
研究领域

Inflammation/Immunology
适应症

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化学信息

CAS Number

1405-86-3
分子量

822.93
分子式

C42H62O16
纯度

>98% (HPLC)
溶解度

Ethanol: 165 mg/mL (200.5 mM); Water: 20 mg/mL (24.3 mM); DMSO: 117 mg/mL (142.17 mM)
SMILES

O[C@@H]([C@@H]([C@@H](C(O)=O)O1)O)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O2)O)O)O)[C@H]1O[C@@H](C(C)([C@](CC[C@@]([C@@]3(CC[C@]4(CC[C@](C[C@]4(C3=C5)[H])(C(O)=O)C)C)C)6C)7[H])C)CC[C@]7(C)[C@@]6([H])C5=O
化学全称

(2S,3S,4S,5R,6R)-6-(((2S,3R,4S,5S,6S)-6-carboxy-2-(((3R,4aR,6aR,6bS,8aS,11R,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid