Glycerol

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Glycerol or glycerin is a colourless odourless viscous liquid that is sweet-tasting and mostly non-toxic.

Glycerol or glycerin is a colourless odourless viscous liquid that is sweet-tasting and mostly non-toxic. It is widely used in the food industry as a sweetener and humectant and in pharmaceutical formulations. Glycerol is an important component of triglycerides (i.e. fats and oils) and of phospholipids. Glycerol is a three-carbon substance that forms the backbone of fatty acids in fats. When the body uses stored fat as a source of energy glycerol and fatty acids are released into the bloodstream. The glycerol component can be converted into glucose by the liver and provides energy for cellular metabolism. Normally glycerol shows very little acute toxicity and very high oral doses or acute exposures can be tolerated. On the other hand chronically high levels of glycerol in the blood are associated with glycerol kinase deficiency (GKD). GKD causes the condition known as hyperglycerolemia an accumulation of glycerol in the blood and urine. There are three clinically distinct forms of GKD: infantile juvenile and adult. The infantile form is the most severe and is associated with vomiting lethargy severe developmental delay and adrenal insufficiency. The mechanisms of glycerol toxicity in infants are not known but it appears to shift metabolism towards chronic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis the initial symptoms include poor feeding vomiting loss of appetite weak muscle tone (hypotonia) and lack of energy (lethargy). These can progress to heart liver and kidney abnormalities seizures coma and possibly death. These are also the characteristic symptoms of untreated GKD. Many affected children with organic acidemias experience intellectual disability or delayed development. Patients with the adult form of GKD generally have no symptoms and are often detected fortuitously.

Glycerin

Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite

Others

Constipation cerebral edema

56-81-5

92.09

C3H8O3

>98% (HPLC)

DMSO:≥300 mg/mL (3257.68 mM);Water:>500mg/ml

OCC(O)CO

propane-123-triol

(-20℃)

With Ice Pack

≥ 2 years