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Oleoylethanolamide
CAS No. 111-58-0
Oleoylethanolamide ( N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide )
产品货号. M22670 CAS No. 111-58-0
Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥316 | 有现货 |
|
| 5MG | ￥518 | 有现货 |
|
| 10MG | ￥786 | 有现货 |
|
| 25MG | ￥1531 | 有现货 |
|
| 50MG | ￥2811 | 有现货 |
|
| 100MG | ￥4496 | 有现货 |
|
| 200MG | ￥6253 | 有现货 |
|
| 500MG | ￥9558 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Oleoylethanolamide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.
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产品描述Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.Treatment with OEA (5 mg/kg/day, intraperitoneal injection, i.p.) significantly attenuated the progress of liver fibrosis in both two experimental animal models by blocking the activation of hepatic stellate cells (HSCs).?Gene expression analysis of hepatic tissues indicated that OEA inhibited the expression of α-smooth muscle action (α-SMA) and collagen matrix, fibrosis markers, and genes involved in inflammation and extracellular matrix remodeling.?
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同义词N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide
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通路Proteasome/Ubiquitin
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靶点Endogenous Metabolite
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受体Human Endogenous Metabolite;PPARα
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研究领域——
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适应症——
化学信息
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CAS Number111-58-0
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分子量325.53
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分子式C20H39NO2
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纯度>98% (HPLC)
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溶解度DMSO:19.83 mg/mL (60.92 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
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SMILESCCCCCCCC\C=C/CCCCCCCC(=O)NCCO
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Chen L, et al. Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells. Oncotarget. 2015 Dec 15;6(40):42530-40
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