
Gelsemine
CAS No. 509-15-9
Gelsemine ( —— )
产品货号. M18681 CAS No. 509-15-9
钩吻明对炎症性疼痛、神经性疼痛和骨癌性疼痛具有显着的镇痛作用,且不会引起镇痛耐受。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1288 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Gelsemine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述钩吻明对炎症性疼痛、神经性疼痛和骨癌性疼痛具有显着的镇痛作用,且不会引起镇痛耐受。
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产品描述Gelsemine has antitumor activity. Gelsemine has anti-oxidative activity. Gelsemine has anti-hyperlipidemic activity. Gelsemine has marked antinociception in inflammatory, neuropathic and bone cancer pains without inducing antinociceptive tolerance. (In Vivo):Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice.Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%.
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体外实验——
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体内实验Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice. Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域Others-Field
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适应症——
化学信息
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CAS Number509-15-9
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分子量322.4
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分子式C20H22N2O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (310.17 mM)
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SMILESCN1CC2(C3CC4C5(C2C1C3CO4)C6=CC=CC=C6NC5=O)C=C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册




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