
Lucerastat
CAS No. 141206-42-0
Lucerastat ( N-Butyldeoxygalactonojirimycin | ACT-434964 | OGT-923 )
产品货号. M11715 CAS No. 141206-42-0
一种半乳糖类似物,是一种 UDP-葡萄糖神经酰胺葡萄糖基转移酶 (UGCG/GCS) 抑制剂 (IC50=41.4 uM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
50MG | ¥8060 | 有现货 |
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100MG | ¥14256 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Lucerastat
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述一种半乳糖类似物,是一种 UDP-葡萄糖神经酰胺葡萄糖基转移酶 (UGCG/GCS) 抑制剂 (IC50=41.4 uM)。
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产品描述A galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM); prevents glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders, without affecting α-glucosidase I and II or β-glucocerebrosidase (IC50>1 mM); shows potential as substrate reduction therapy for glycolipid storage disorders such as Gaucher disease and Fabry disease.Other Indication Phase 1 Clinical.
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体外实验Fabry patient-derived fibroblasts with the genotypes R301G (residual -GalA activity; 20%) R220X (<3%) and W162X (<1%). Cell Viability Assay.Cell Line:Fabry patient-derived fibroblasts with the genotypes R301G (residual-GalA activity; 20%) R220X (<3%) and W162X (<1%). Concentration:Incubation Time:9 days.Result:Dose-dependently inhibited GCS, reducing glucosylceramide and increasing sphingomyelin.
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体内实验Lucerastat (1200 mg/kg/day food admix), a GCS inhibitor, reduces Gb3 in the absence of residual-GalA activity. Animal Model:Fabry mice (Gla-/0 and Gla-/-, n = 5 or 6 for each gender).Dosage:1200 mg/kg/day food admix.Administration:Food admix for 20 weeks.Result:Reduced lipid storage in two major organs affected by FD: mean Gb3 in the kidneys (-33%, p<0.01). and α-galactose- terminated glycosphingolipids in the dorsal root ganglia (-48%, p<0.05). In the liver of the Fabry mice, mean glucosylceramide (GlcCer (24:0)) was reduced (-59%, p<0.001) in addition to Gb3 (24:1) (-37%, p<0.05) demonstrating substrate reduction through GCS inhibition.
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同义词N-Butyldeoxygalactonojirimycin | ACT-434964 | OGT-923
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number141206-42-0
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分子量219.281
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分子式C10H21NO4
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纯度>98% (HPLC)
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溶解度In Vitro:?H2O : 24 mg/mL (109.45 mM)
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SMILESO[C@H]1[C@@H](CO)N(CCCC)C[C@H](O)[C@H]1O
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化学全称(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Platt FM, et al. J Biol Chem. 1994 Oct 28;269(43):27108-14.
2. Andersson U, et al. Biochem Pharmacol. 2000 Apr 1;59(7):821-9.
3. Kasperzyk JL, et al. J Neurochem. 2004 May;89(3):645-53.
产品手册




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