Gboxin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gboxin 是一种小分子，可特异性抑制原代小鼠和人胶质母细胞瘤细胞的生长（原代 GBM IC50=150 nM）。

Gboxin is a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells (primary GBM IC50=150 nM) but not that of mouse embryonic fibroblasts or neonatal astrocytes; Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma, inhibits the activity of F0F1 ATP synthase, mirrors oligomycin activity and resistance requires functional mPTP.

Gboxin (0-15 μM; 96 hours) specifically inhibit the growth of primary ‘high-throughput GBM sphere’ (HTS) cells but not that of cycling primary low-passage mouse embryonic fibroblasts (MEFs) or astrocytes. Cell Viability Assay Cell Line:HTS cells, MEFs and astrocytes Concentration:0, 185, 555, 1667, 5000, 15000 nM Incubation Time:96 hours Result:Inhibited the growth of HTS cells (IC50=150 nM).

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Gboxin | Gboxin chloride

Endocrinology/Hormones

ATPase

ATPase

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2101315-36-8

392.968

C22H33ClN2O2

>98% (HPLC)

DMSO : 32.5 mg/mL 82.71 mM

C[N+]1=C(CC)N(CC(O[C@H]2[C@H](C(C)C)CC[C@@H](C)C2)=O)C3=CC=CC=C31.[Cl-]

2-ethyl-1-(2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-3-methyl-1H-benzo[d]imidazol-3-ium chloride

(-20℃)

With Ice Pack

≥ 2 years