Gboxin ( Gboxin; Gboxin chloride )

产品货号. M13335 CAS No. 2101315-36-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Gboxin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Gboxin is a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells (primary GBM IC50=150 nM).
产品描述

Gboxin is a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells (primary GBM IC50=150 nM) but not that of mouse embryonic fibroblasts or neonatal astrocytes; Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma, inhibits the activity of F0F1 ATP synthase, mirrors oligomycin activity and resistance requires functional mPTP.
同义词

Gboxin; Gboxin chloride
通路

Endocrinology/Hormones
靶点

ATPase
受体

ATPase
研究领域

——
适应症

——

CAS Number

2101315-36-8
分子量

392.97
分子式

C22H33ClN2O2
纯度

>98% (HPLC)
溶解度

DMSO : 32.5 mg/mL 82.71 mM
SMILES

C[N+]1=C(CC)N(CC(O[C@H]2[C@H](C(C)C)CC[C@@H](C)C2)=O)C3=CC=CC=C31.[Cl-]
化学全称

2-ethyl-1-(2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-3-methyl-1H-benzo[d]imidazol-3-ium chloride

1. Shi Y, et al. Nature. 2019 Mar;567(7748):341-346.

计算器

产品手册

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