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Ganaplacide
CAS No. 1261113-96-5
Ganaplacide ( KAF156;GNF-156 )
产品货号. M11081 CAS No. 1261113-96-5
Ganaplacide (KAF156, GNF-156)is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥11097 | 有现货 |
|
| 50MG | ￥22518 | 有现货 |
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| 100MG | ￥29970 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Ganaplacide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Ganaplacide (KAF156, GNF-156)is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.
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产品描述Ganaplacide (KAF156, GNF-156)is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains; demonstrates potent therapeutic activity in mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4 mg/kg, respectively; KAF156 is completely protective as a single oral dose of 10 mg/kg in sporozoite challenge mouse model; shows the potential to treat, prevent, and block the transmission of malaria.Parasite Infection Phase 2 Clinical
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同义词KAF156;GNF-156
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通路Microbiology/Virology
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靶点Parasite
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受体Parasite
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研究领域Infection
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适应症Parasite Infection
化学信息
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CAS Number1261113-96-5
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分子量411.46
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分子式C22H23F2N5O
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1(C)C2=NC(C3=CC=C(F)C=C3)=C(NC4=CC=C(F)C=C4)N2CCN1C(CN)=O
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化学全称2-amino-1-[3-(4-fluoroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]ethan-1-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kuhen KL, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5060-7.
2. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6437-43.
3. Lim MY, et al. Nat Microbiol. 2016 Sep 19:16166.
4. White NJ, et al. N Engl J Med. 2016 Sep 22;375(12):1152-60.
2. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6437-43.
3. Lim MY, et al. Nat Microbiol. 2016 Sep 19:16166.
4. White NJ, et al. N Engl J Med. 2016 Sep 22;375(12):1152-60.
产品手册
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