SJ-733
CAS No. 1424799-20-1
SJ-733 ( +)-SJ733;SJ000557733;SJ-557733 )
产品货号. M11792 CAS No. 1424799-20-1
SJ-733 (SJ000557733;SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥4755 | 有现货 |
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50MG | ¥24057 | 有现货 |
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100MG | ¥33858 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称SJ-733
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述SJ-733 (SJ000557733;SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite.
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产品描述SJ-733 (SJ000557733;SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite; displays high potency in vitro against all tested strains of P. falciparum with EC50 of 10-60 nM; kills parasites and the high fitness cost associated with resistance-conferring mutations appear to slow and suppress the selection of highly drug-resistant mutants in vivo; high oral bioavailabilityParasite Infection Phase 1 Clinical
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同义词+)-SJ733;SJ000557733;SJ-557733
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通路Microbiology/Virology
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靶点Parasite
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受体Parasite
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研究领域Infection
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适应症Parasite Infection
化学信息
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CAS Number1424799-20-1
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分子量468.41
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分子式C24H16F4N4O2
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纯度>98% (HPLC)
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溶解度DMSO : 50 mg/mL 106.75 mM
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SMILESO=C([C@@H](C1=C2C=CC=C1)[C@@H](C3=CC=CN=C3)N(CC(F)(F)F)C2=O)NC4=CC=C(F)C(C#N)=C4
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化学全称(3S,4S)-N-(3-Cyano-4-fluorophenyl)-1-oxo-3-(3-pyridinyl)-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydro-4-isoquinolinecarboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Jiménez-Díaz MB, et al. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62.
2. Crawford ED, et al. PLoS One. 2017 May 22;12(5):e0178163.
3. Mogollon CM, et al. PLoS One. 2016 Dec 20;11(12):e0168362.
2. Crawford ED, et al. PLoS One. 2017 May 22;12(5):e0178163.
3. Mogollon CM, et al. PLoS One. 2016 Dec 20;11(12):e0168362.
产品手册
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