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SJ-733

CAS No. 1424799-20-1

SJ-733 ( +)-SJ733;SJ000557733;SJ-557733 )

产品货号. M11792 CAS No. 1424799-20-1

SJ-733 (SJ000557733;SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥4755 有现货
50MG ¥24057 有现货
100MG ¥33858 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    SJ-733
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    SJ-733 (SJ000557733;SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite.
  • 产品描述
    SJ-733 (SJ000557733;SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite; displays high potency in vitro against all tested strains of P. falciparum with EC50 of 10-60 nM; kills parasites and the high fitness cost associated with resistance-conferring mutations appear to slow and suppress the selection of highly drug-resistant mutants in vivo; high oral bioavailabilityParasite Infection Phase 1 Clinical
  • 同义词
    +)-SJ733;SJ000557733;SJ-557733
  • 通路
    Microbiology/Virology
  • 靶点
    Parasite
  • 受体
    Parasite
  • 研究领域
    Infection
  • 适应症
    Parasite Infection

化学信息

  • CAS Number
    1424799-20-1
  • 分子量
    468.41
  • 分子式
    C24H16F4N4O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 50 mg/mL 106.75 mM
  • SMILES
    O=C([C@@H](C1=C2C=CC=C1)[C@@H](C3=CC=CN=C3)N(CC(F)(F)F)C2=O)NC4=CC=C(F)C(C#N)=C4
  • 化学全称
    (3S,4S)-N-(3-Cyano-4-fluorophenyl)-1-oxo-3-(3-pyridinyl)-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydro-4-isoquinolinecarboxamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Jiménez-Díaz MB, et al. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62.
2. Crawford ED, et al. PLoS One. 2017 May 22;12(5):e0178163.
3. Mogollon CM, et al. PLoS One. 2016 Dec 20;11(12):e0168362.
产品手册
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