GSK429286A ( GSK429286A; GSK 429286A )

产品货号. M17626 CAS No. 864082-47-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GSK429286A
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
产品描述

GSK429286A is a selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.
同义词

GSK429286A; GSK 429286A
通路

Others
靶点

Other Targets
受体

ROCK1; ROCK2
研究领域

Cancer
适应症

——

CAS Number

864082-47-3
分子量

432.37
分子式

C21H16F4N4O2
纯度

98%
溶解度

DMSO : ≥ 51 mg/mL; 117.95 mM
SMILES

CC1=C(C(CC(=O)N1)c1ccc(cc1)C(F)(F)F)C(=O)Nc1c(cc2c(c1)cn[nH]2)F
化学全称

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide

1. Goodman KB, et al. J Med Chem, 2007, 50(1), 6-9.

计算器

产品手册

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