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4-Hydroxyisoleucine

CAS No. 781658-23-9

4-Hydroxyisoleucine ( 4-?Hydroxy-?L-?isoleucine )

产品货号. M20779 CAS No. 781658-23-9

4-羟基异亮氨酸具有抗抑郁样、抗血脂异常和抗高血糖作用。它显示出促胰岛素活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥485 有现货
5MG ¥697 有现货
10MG ¥1244 有现货
25MG ¥2240 有现货
50MG ¥3360 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    4-Hydroxyisoleucine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    4-羟基异亮氨酸具有抗抑郁样、抗血脂异常和抗高血糖作用。它显示出促胰岛素活性。
  • 产品描述
    4-Hydroxyisoleucine has antidepressant-like antidyslipidemic and antihyperglycemic effects.?It displays an insulinotropic activity.
  • 体外实验
    Cell Viability Assay Cell Line:RAW264.7 macrophages and 3 T3-L1 adipocytes Concentration:0-20 μM Incubation Time:6 h Result:Didn’t affect the cell viability.Cell Migration Assay Cell Line:RAW264.7 macrophages and 3 T3-L1 adipocytes Concentration:20 μM Incubation Time:24 h Result:Inhibited the migration of RAW264.7 macrophages in 3 T3-L1 adipocytes.Western Blot Analysis Cell Line:L6-GLUT4mycConcentration:25 μM Incubation Time:16 h Result:Increased the AKT (Ser-473) phosphorylation.
  • 体内实验
    Animal Model:Fructose-fed rat Dosage:50 mg/kg Administration:Oral gavage (p.o.), daily, 8 weeksResult:Decreased the levels of glucose and ALT.Reduced 80% of fructosehe-induced AST release to 151 ± 45 U/mL.Animal Model:Type 2 diabetic rat Dosage:50 mg/kg Administration:i.g., daily, 14 days Result:Restored the level of HDL-cholesterol to levels comparable to controls.Animal Model:Male C57BL/6 mice Dosage:50-200 mg/kg Administration: Oral gavage (p.o.), 8 weeks Result:Decreases the body weights of mice in a dose-dependent manner.Decreased blood glucose levels and fasting plasma insulin content in mice.Decreased the expression of TLR4, inhibited the phosphorylation of JNK, and increased the production of IκB-α.Animal Model:Type 1 diabetic ratDosage:50 mg/kg Administration: i.g., daily, 14 days Result:Improved appearance and heavy ocular vascularization.Reduced the blood glucose from 500 mg/dl to 330 mg/dl.Decreased the levels of lipid markers (TG, LDL and HDL) and uric acid.
  • 同义词
    4-?Hydroxy-?L-?isoleucine
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    781658-23-9
  • 分子量
    147.17
  • 分子式
    C6H13NO3
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?H2O : 100 mg/mL (679.49 mM)
  • SMILES
    CC(O)[C@H](C)[C@H](N)C(=O)O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Anaguiven A S Ricardo C C Jorge R et al. 4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity[J]. Molecules 2016 21(11):1596-.
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