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4-Hydroxyisoleucine
CAS No. 781658-23-9
4-Hydroxyisoleucine ( 4-?Hydroxy-?L-?isoleucine )
产品货号. M20779 CAS No. 781658-23-9
4-羟基异亮氨酸具有抗抑郁样、抗血脂异常和抗高血糖作用。它显示出促胰岛素活性。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥485 | 有现货 |
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5MG | ¥697 | 有现货 |
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10MG | ¥1244 | 有现货 |
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25MG | ¥2240 | 有现货 |
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50MG | ¥3360 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称4-Hydroxyisoleucine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述4-羟基异亮氨酸具有抗抑郁样、抗血脂异常和抗高血糖作用。它显示出促胰岛素活性。
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产品描述4-Hydroxyisoleucine has antidepressant-like antidyslipidemic and antihyperglycemic effects.?It displays an insulinotropic activity.
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体外实验Cell Viability Assay Cell Line:RAW264.7 macrophages and 3 T3-L1 adipocytes Concentration:0-20 μM Incubation Time:6 h Result:Didn’t affect the cell viability.Cell Migration Assay Cell Line:RAW264.7 macrophages and 3 T3-L1 adipocytes Concentration:20 μM Incubation Time:24 h Result:Inhibited the migration of RAW264.7 macrophages in 3 T3-L1 adipocytes.Western Blot Analysis Cell Line:L6-GLUT4mycConcentration:25 μM Incubation Time:16 h Result:Increased the AKT (Ser-473) phosphorylation.
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体内实验Animal Model:Fructose-fed rat Dosage:50 mg/kg Administration:Oral gavage (p.o.), daily, 8 weeksResult:Decreased the levels of glucose and ALT.Reduced 80% of fructosehe-induced AST release to 151 ± 45 U/mL.Animal Model:Type 2 diabetic rat Dosage:50 mg/kg Administration:i.g., daily, 14 days Result:Restored the level of HDL-cholesterol to levels comparable to controls.Animal Model:Male C57BL/6 mice Dosage:50-200 mg/kg Administration: Oral gavage (p.o.), 8 weeks Result:Decreases the body weights of mice in a dose-dependent manner.Decreased blood glucose levels and fasting plasma insulin content in mice.Decreased the expression of TLR4, inhibited the phosphorylation of JNK, and increased the production of IκB-α.Animal Model:Type 1 diabetic ratDosage:50 mg/kg Administration: i.g., daily, 14 days Result:Improved appearance and heavy ocular vascularization.Reduced the blood glucose from 500 mg/dl to 330 mg/dl.Decreased the levels of lipid markers (TG, LDL and HDL) and uric acid.
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同义词4-?Hydroxy-?L-?isoleucine
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number781658-23-9
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分子量147.17
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分子式C6H13NO3
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纯度>98% (HPLC)
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溶解度In Vitro:?H2O : 100 mg/mL (679.49 mM)
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SMILESCC(O)[C@H](C)[C@H](N)C(=O)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Anaguiven A S Ricardo C C Jorge R et al. 4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity[J]. Molecules 2016 21(11):1596-.
产品手册
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