GSK4112 ( SR6452;GSK-4112;GSK 4112;SR-6452;SR 6452 )

产品货号. M10812 CAS No. 1216744-19-2

A potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assay.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥348	有现货
10MG	￥624	有现货
25MG	￥1320	有现货
50MG	￥2398	有现货
100MG	￥4301	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

拼团产品询价大包装询价加入购物车

生物学信息

产品名称

GSK4112
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assay.
产品描述

A potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assay; mediates the repression of Rev-erbα target gene bmal1 in liver cells, and inhibits and shifts the phase of gluconeogenesis in primary mouse hepatocytes.
同义词

SR6452;GSK-4112;GSK 4112;SR-6452;SR 6452
通路

Autophagy
靶点

Autophagy
受体

Rev-ErbBα
研究领域

Metabolic Disease
适应症

——

化学信息

CAS Number

1216744-19-2
分子量

396.89
分子式

C18H21ClN2O4S
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

O=C(OC(C)(C)C)CN(CC1=CC=C(Cl)C=C1)CC2=CC=C([N+]([O-])=O)S2
化学全称

Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Grant D, et al. ACS Chem Biol. 2010 Oct 15;5(10):925-32.
2. Trump RP, et al. J Med Chem. 2013 Jun 13;56(11):4729-37.
3. Chandra V, et al. Autophagy. 2015 Nov 2;11(11):1987-1997.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册

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