021-51111890
购物车（）
sales@molnova.cn
GSK4112
CAS No. 1216744-19-2
GSK4112 ( SR6452;GSK-4112;GSK 4112;SR-6452;SR 6452 )
产品货号. M10812 CAS No. 1216744-19-2
A potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assay.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥348 | 有现货 |
|
| 10MG | ￥624 | 有现货 |
|
| 25MG | ￥1320 | 有现货 |
|
| 50MG | ￥2398 | 有现货 |
|
| 100MG | ￥4301 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称GSK4112
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assay.
-
产品描述A potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assay; mediates the repression of Rev-erbα target gene bmal1 in liver cells, and inhibits and shifts the phase of gluconeogenesis in primary mouse hepatocytes.
-
同义词SR6452;GSK-4112;GSK 4112;SR-6452;SR 6452
-
通路Autophagy
-
靶点Autophagy
-
受体Rev-ErbBα
-
研究领域Metabolic Disease
-
适应症——
化学信息
-
CAS Number1216744-19-2
-
分子量396.89
-
分子式C18H21ClN2O4S
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO
-
SMILESO=C(OC(C)(C)C)CN(CC1=CC=C(Cl)C=C1)CC2=CC=C([N+]([O-])=O)S2
-
化学全称Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Grant D, et al. ACS Chem Biol. 2010 Oct 15;5(10):925-32.
2. Trump RP, et al. J Med Chem. 2013 Jun 13;56(11):4729-37.
3. Chandra V, et al. Autophagy. 2015 Nov 2;11(11):1987-1997.
2. Trump RP, et al. J Med Chem. 2013 Jun 13;56(11):4729-37.
3. Chandra V, et al. Autophagy. 2015 Nov 2;11(11):1987-1997.
产品手册
关联产品
-
Dilmapimod
Dilmapimod is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.
-
UVI 3003
UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively).
-
DMXAA
A vascular disrupting agent (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 uM; activates STING dependent innate immune pathways.
