GSK3-IN-3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GSK3-IN-3 是一种线粒体自噬 (mitophagy) 诱导剂，可诱导帕金依赖性线粒体自噬。GSK3-IN-3 也是一种 GSK-3 抑制剂，IC50 值为 3.01 μM。 GSK3-IN-3 具有非 ATP 和非底物竞争性，对 6-OHDA 有神经保护作用。

GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA.

ImmunofluorescenceCell Line:Parkin-expressing U2OS-iMLS cells Concentration:1.56 μM, 3.12 μM, 6.25 μM, 12.5 μM, and 25 μM; Incubation Time:24 hour sResult:Induced a mitochondrial morphology change from a filament-shaped network to a more round-shaped network.Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:0.5 μM, 1 μM, 3 μM, 5 μM, and 10 μM Incubation Time:16 hours; with 35 μM 6-OHDA Result:Inhibited cell growth with an IC50 value of 2.57 μM.

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PI3K/Akt/mTOR signaling

GSK-3

Mitophagy | GSK-3

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331963-27-0

429.55

C24H35N3O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 4.17 mg/mL (9.71 mM; 超声助溶 (<60°C)

C(C)N1C=2C(C(O)=C(C(NNC(CCCCCCCCCCC)=O)=O)C1=O)=CC=CC2

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(-20℃)

With Ice Pack

≥ 2 years