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CHIR-98014
CAS No. 252935-94-7
CHIR-98014 ( CHIR98014 | CHIR 98014 )
产品货号. M13748 CAS No. 252935-94-7
CHIR-98014 是一种有效的选择性糖原合酶激酶 3 (GSK-3)，对 GSK-3α 和 GSK-3β 的 IC50 值分别为 0.65 和 0.58 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥551 | 有现货 |
|
| 10MG | ￥883 | 有现货 |
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| 25MG | ￥1847 | 有现货 |
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| 50MG | ￥3013 | 有现货 |
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| 100MG | ￥4836 | 有现货 |
|
| 500MG | ￥10206 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CHIR-98014
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CHIR-98014 是一种有效的选择性糖原合酶激酶 3 (GSK-3)，对 GSK-3α 和 GSK-3β 的 IC50 值分别为 0.65 和 0.58 nM。
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产品描述CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; shows less potent activities against 20 other protein kinases including Cdc2 and Erk2; causes GS stimulation in CHO-IR cells and rat hepatocytes, with EC50s of 106 nM and 107 nM, respectively; reduces the viability of ES-CCE cells with IC50 of 1.1 uM, results in a significant activation of the Wnt/beta-catenin pathway in ES-D3 cells combined with CHIR-99021; significantly reduces fasting hyperglycemia within and shows improved glucose disposal in diabetic and insulin-resistant db/db mice.
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体外实验——
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体内实验——
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同义词CHIR98014 | CHIR 98014
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通路PI3K/Akt/mTOR signaling
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靶点GSK-3
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受体bFGFR|c-Src|GSK-3α|GSK-3β|p70S6K
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研究领域——
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适应症——
化学信息
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CAS Number252935-94-7
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分子量486.3141
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分子式C20H17Cl2N9O2
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纯度>98% (HPLC)
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溶解度DMSO: 11 mg/mL
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SMILESNC1=C(C=CC(NCCNC2=NC=C(N3C=CN=C3)C(=N2)C2=C(Cl)C=C(Cl)C=C2)=N1)[N+]([O-])=O
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化学全称2,6-Pyridinediamine, N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ring DB, et al. Diabetes. 2003 Mar;52(3):588-95.
2. Lian X, et al. Cell Reports. 2015 Jan 13;4(1):170.
