GSK-656
CAS No. 2131798-13-3
GSK-656 ( GSK656;GSK 656;GSK3036656;GSK-3036656 )
产品货号. M13395 CAS No. 2131798-13-3
GSK-656 (GSK-3036656, GSK656)is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥11907 | 有现货 |
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50MG | ¥24138 | 有现货 |
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100MG | ¥32400 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GSK-656
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述GSK-656 (GSK-3036656, GSK656)is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
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产品描述GSK-656 (GSK-3036656, GSK656)is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM; displays no significant activity for human mitochondrial LeuRS and human cytoplasmic LeuRS (IC50>100 uM); shows potent antitubercular activity (Mtb H37Rv IC50=0.08 uM) in vitro; exhibits remarkable PK profiles and efficacy against Mtb in mouse TB infection models.Bacterial Infection Phase 1 Clinical
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同义词GSK656;GSK 656;GSK3036656;GSK-3036656
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通路GPCR/G Protein
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靶点Antibacterial
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受体Antibacterial
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研究领域Infection
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适应症Bacterial Infection
化学信息
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CAS Number2131798-13-3
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分子量293.94
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分子式C10H14BCl2NO4
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纯度>98% (HPLC)
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溶解度DMSO : 67.5 mg/mL 229.64 mM
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SMILESB1(C2=C(C=CC(=C2C(O1)CN)Cl)OCCO)O.Cl
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化学全称(S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c]-[1,2]oxaborol-1(3H)-ol hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Li X,et al. J Med Chem. 2017 Oct 12;60(19):8011-8026.
产品手册
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