GSK693 ( GSK-693 | GSK 693 )

产品货号. M11537 CAS No. 1372891-37-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GSK693
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GSK693 (GSK-693) 是一种有效的结核分枝杆菌烯酰-ACP 还原酶 (InhA) 直接抑制剂，IC50 为 7 nM。
产品描述

GSK693 (GSK-693) is a potent, direct inhibitor of M. tuberculosis enoyl-ACP reductase (InhA) with IC50 of 7 nM, shows equally potent activity against M. tuberculosis H37Rv both intra and extracellularly (MIC=0.2 uM); exhibits activities against multidrug (MDR) and extensively (XDR) drug-resistant clinical isolates as well as in TB murine models when orally dosed.
体外实验

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体内实验

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同义词

GSK-693 | GSK 693
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

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适应症

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CAS Number

1372891-37-6
分子量

419.54
分子式

C16H17N7OS3
纯度

>98% (HPLC)
溶解度

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SMILES

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化学全称

(S)-1-(4-methylthiazol-2-yl)-1-(5-((1-((2-methylthiazol-4-yl)methyl)-1H-pyrazol-3-yl)amino)-1,3,4-thiadiazol-2-yl)ethanol

1. Martínez-Hoyos M, et al. EBioMedicine. 2016 Jun;8:291-301.

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产品手册

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