
GSK-626616
CAS No. 1025821-33-3
GSK-626616 ( —— )
产品货号. M26702 CAS No. 1025821-33-3
GSK-626616 是一种有效的口服生物可利用的 DYRK3 抑制剂 (IC50: 0.7 nM)。它以类似的效力抑制 DYRK 家族的其他成员。 GSK-626616 是治疗贫血的潜在疗法。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥786 | 有现货 |
![]() ![]() |
10MG | ¥1256 | 有现货 |
![]() ![]() |
25MG | ¥2398 | 有现货 |
![]() ![]() |
50MG | ¥4431 | 有现货 |
![]() ![]() |
100MG | ¥6391 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称GSK-626616
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述GSK-626616 是一种有效的口服生物可利用的 DYRK3 抑制剂 (IC50: 0.7 nM)。它以类似的效力抑制 DYRK 家族的其他成员。 GSK-626616 是治疗贫血的潜在疗法。
-
产品描述GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.(In Vitro):GSK-626616 (serum-deprived HeLa cells) reduces EGF-induced phosphorylation of PRAS40 at Thr246. Binding of PRAS40 to mTORC1 is enhanced by GSK-626616.GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells. GSK-626616 reduces the phosphorylation of S6K1 at Thr389 in EGF- and insulin-stimulated HeLa cells, showing that mTORC1 activity is impaired.
-
体外实验GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells. GSK-626616 reduces the phosphorylation of S6K1 at Thr389 in EGF- and insulin-stimulated HeLa cells, showing that mTORC1 activity is impaired.GSK-626616 (serum-deprived HeLa cells) reduces EGF-induced phosphorylation of PRAS40 at Thr246. Binding of PRAS40 to mTORC1 is enhanced by GSK-626616.
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Cereblon| Molecular Glues| TNF-α
-
研究领域——
-
适应症——
化学信息
-
CAS Number1025821-33-3
-
分子量401.27
-
分子式C18H10Cl2N4OS
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 50 mg/mL (124.60 mM)
-
SMILESClc1cccc(Cl)c1NC1=NC(=O)\C(S1)=C\c1ccc2nccnc2c1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Lopez-Girona A, et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia. 2012 Nov;26(11):2326-35.
产品手册




关联产品
-
3-Acetylcoumarin
3-乙酰香豆素作为室温下铜催化 CN 偶联反应的实用配体。它具有神经保护和杀螨特性。
-
Ganoderic acid LM2
Ganoderic acid LM2 exhibits potent enhancement of ConA-induced mice splenocytes proliferation in vitro.
-
HIV-1 TAT 48-60
HIV-1 TAT (48-60) is a cell-penetrating peptide derived from the human immunodeficient virus (HIV)-1 Tat protein residue 48-60. This is one of the cell-penetrating peptides generated from the human immunodeficient virus -1 Tat protein residue 48-60.