
Azosemide
CAS No. 27589-33-9
Azosemide ( —— )
产品货号. M26067 CAS No. 27589-33-9
Azosemide 是一种有效的 NKCC1 抑制剂(对于 hNKCC1A 和 NKCC1B,IC50 分别为 0.246 μM 和 0.197 μM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥340 | 有现货 |
![]() ![]() |
25MG | ¥551 | 有现货 |
![]() ![]() |
50MG | ¥786 | 有现货 |
![]() ![]() |
100MG | ¥1199 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Azosemide
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Azosemide 是一种有效的 NKCC1 抑制剂(对于 hNKCC1A 和 NKCC1B,IC50 分别为 0.246 μM 和 0.197 μM)。
-
产品描述Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246?μM and 0.197?μM for hNKCC1A and NKCC1B).(In Vitro):Azosemide inhibits the sodium-potassium-chloride-cotransporter human variants hNKCC1B and hNKCC1A .(In Vivo):Azosemide shows a shorter terminal half-life (50.9% decrease) and MRT (64.1% decrease), smaller AUC (81.9% decrease), faster CL (454% increase), CLNR (307% increase) and CLR (853% increase) for NARs .
-
体外实验Azosemide inhibits the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B.
-
体内实验Azosemide shows a smaller AUC (81.9% decrease), shorter terminal half-life (50.9% decrease) and MRT (64.1% decrease), faster CL (454% increase), CLR (853% increase) and CLNR (307% increase) for NARs. Animal Model:Male Sprague-Dawley rats (control rats, weighing 310345 g) and NARs (weighing 220315 g) of 9 weeks of age Dosage:10 mg/kg (Pharmacokinetic Analysis) Administration:Infused over 1 min via the jugular vein (i.v.)Result:Showed a smaller AUC (81.9% decrease), shorter terminal half-life (50.9% decrease) and MRT (64.1% decrease), faster CL (454% increase), CLR (853% increase) and CLNR (307% increase) for NARs.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number27589-33-9
-
分子量370.83
-
分子式C12H11ClN6O2S2
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 250 mg/mL (674.15 mM)
-
SMILESNS(=O)(=O)c1cc(-c2nnn[nH]2)c(NCc2cccs2)cc1Cl
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
产品手册




关联产品
-
2-Amino-5-chlorobenz...
用作医药中间体,主要用于制备利布丁、安定、艾司唑仑等镇静化合物。
-
His-Pro
His-Pro is a dipeptide consisting of histidyl and proline.
-
Acein
High affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Exhibits no significant effect on ACE enzymatic activity up to 500 nM concentration. Potentiates NMDA + D-serine-induced dopamine release from striatal slices in vitro and the striatum in vivo.