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BAY524
CAS No. 1445830-39-6
BAY524 ( —— )
产品货号. M22177 CAS No. 1445830-39-6
BAY-524 是 Bub1 的抑制剂（在 2 mM ATP 存在下，IC50 = 450 nM.人 Bub1）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2657 | 有现货 |
|
| 10MG | ￥4479 | 有现货 |
|
| 25MG | ￥7233 | 有现货 |
|
| 50MG | ￥9882 | 有现货 |
|
| 100MG | ￥13365 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BAY524
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BAY-524 是 Bub1 的抑制剂（在 2 mM ATP 存在下，IC50 = 450 nM.人 Bub1）。
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产品描述BAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).
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体外实验BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM.BAY-524 (7-10 μM or 0-30 μM; 14 h or 1 h) specifically inhibit Bub1 kinase.BAY-524 (7 μM , 12 h or 7 μM, 12 μM, 3 h) affects Sgo1 and Sgo2 localization and chromatid cohesion in cells.BAY-524 (7 μM, 10 μM) affects localization and activity of the CPC.BAY-524 (7 μM, 2 h) exerts additive effect on centromere association of CPC.BAY-524 (7 μM, 48 h) marginally affects SAC signaling.BAY-524 (7 μM, 10 μM) sensitizes cells to low doses of paclitaxel. Western Blot Analysis Cell Line:hTERT-RPE1 (RPE1) and HeLa cells Concentration:7-10 μM Incubation Time:14 hResult:Drastically reduced T120 phosphorylation.Immunofluorescence Cell Line:RPE1 and HeLa cells Concentration:0-30 μM Incubation Time:1 hResult:Reduced histone H2A-T120 phosphorylation.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Bub1
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研究领域——
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适应症——
化学信息
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CAS Number1445830-39-6
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分子量482.48
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分子式C24H24F2N6O3
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纯度>98% (HPLC)
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溶解度DMSO:150 mg/mL?(310.89 mM;?Need ultrasonic)
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SMILESCCOc1cc(F)c(Cn2nc(c(C)c2OC)-c2ncc(OC)c(Nc3ccncc3)n2)c(F)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Baron AP, et al. Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. Elife. 2016 Feb 17;5. pii: e12187.
产品手册
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