GNE-886 ( GNE886 )

产品货号. M13340 CAS No. 2101957-05-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GNE-886
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains.
产品描述

GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains, >100-fold selectivity over BRD9, BRD7, TAF1(2), and BRD4(1); has a highly favorable measured kinetic solubility of 122 uM and is an appropriate in vitro tool compound for the CECR2 bromodomain.
同义词

GNE886
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

Other Indications
适应症

——

CAS Number

2101957-05-3
分子量

498.59
分子式

C28H30N6O3
纯度

>98% (HPLC)
溶解度

——
SMILES

CN(C1CCN(CC1)C2=NC=NC(=C2)C3=CC(=CC=C3)OC)C(=O)C4=CN(C(=O)C5=C4C=CN5)CC=C
化学全称

6-allyl-N-(1-(6-(3-methoxyphenyl)pyrimidin-4-yl)piperidin-4-yl)-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide

1. Crawford TD, et al. ACS Med Chem Lett. 2017 Jun 1;8(7):737-741.

计算器

产品手册

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