GNE-272 ( GNE 272;GNE272 )

产品货号. M13036 CAS No. 1936428-93-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GNE-272
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent and selective the bromodomains of CBP/EP300 inhibitor with IC50 of 0.02 and 0.03 uM for CBP and EP300, respectively.
产品描述

A potent and selective the bromodomains of CBP/EP300 inhibitor with IC50 of 0.02 and 0.03 uM for CBP and EP300, respectively; displays high selectivity over BRD4 (1) and other BRDs (>10 uM); shows antiproliferative effect in hematologic cancer cell lines and modulates MYC expression in vivo; exhibits excellent in vivo PK and antitumor activity in an AML tumor model.
同义词

GNE 272;GNE272
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

Cancer
适应症

——

CAS Number

1936428-93-1
分子量

424.48
分子式

C22H25FN6O2
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 150 mg/mL 353.38 mM
SMILES

CC(N1CCC2=C(C(NC3=C(F)C=C(C4=CN(C)N=C4)C=C3)=NN2[C@H]5CCOC5)C1)=O
化学全称

(S)-1-(3-((2-Fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone

1. Crawford TD, et al. J Med Chem. 2016 Dec 8;59(23):10549-10563.

计算器

产品手册

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