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GNE-220
CAS No. 1199590-75-4
GNE-220 ( GNE220 )
产品货号. M10715 CAS No. 1199590-75-4
GNE-220 是一种有效的选择性 MAP4K4 抑制剂，IC50 为 7 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥10287 | 有现货 |
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| 50MG | ￥20898 | 有现货 |
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| 100MG | ￥27540 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GNE-220
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GNE-220 是一种有效的选择性 MAP4K4 抑制剂，IC50 为 7 nM。
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产品描述GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM; alters HUVEC sprout morphology, shifts the distribution of subcellular protrusion and increases total protrusions, dose-dependently increases the number of β1-integrin in long focal adhesions.
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体外实验GNE-220 also inhibits a few other kinases with IC50s of 9nM, 476 nM and 1.1μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs).
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体内实验——
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同义词GNE220
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通路MAPK/ERK Signaling
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靶点MAP4K
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受体MAP4K
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研究领域——
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适应症——
化学信息
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CAS Number1199590-75-4
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分子量438.539
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分子式C25H26N8
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1=C2C(=NC(=N1)C3=CN(N=C3)C)C4=C(N2)N=CC(=C4)C5=CC=C(C=C5)N6CCN(CC6)C
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化学全称4-Methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Vitorino P, et al. Nature. 2015 Mar 26;519(7544):425-30.
2. Gao X, et al. Cell Biosci. 2016 Oct 28;6:56. eCollection 2016.
