GK921 ( GK921; GK-921; GK 921 )

产品货号. M17119 CAS No. 1025015-40-0

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

GK921
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GK921 is a transglutaminase 2 (TGase) inhibitor.
产品描述

GK921 is a transglutaminase 2 (TGase 2) inhibitor. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0.905 μM). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC.
同义词

GK921; GK-921; GK 921
通路

Others
靶点

Other Targets
受体

TGase
研究领域

Cancer
适应症

——

1. Ku BM,et al. Transglutaminase 2 inhibitor abrogates renal cell carcinoma in xenograft models.J Cancer Res Clin Oncol. 2014 May;140(5):757-67.

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