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GK921
CAS No. 1025015-40-0
GK921 ( GK921; GK-921; GK 921 )
产品货号. M17119 CAS No. 1025015-40-0
GK921 is a transglutaminase 2 (TGase) inhibitor.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥680 | 有现货 |
|
| 5MG | ￥1021 | 有现货 |
|
| 10MG | ￥1677 | 有现货 |
|
| 25MG | ￥2681 | 有现货 |
|
| 50MG | ￥4301 | 有现货 |
|
| 100MG | ￥5873 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GK921
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GK921 is a transglutaminase 2 (TGase) inhibitor.
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产品描述GK921 is a transglutaminase 2 (TGase 2) inhibitor. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0.905 μM). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC.
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同义词GK921; GK-921; GK 921
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通路Others
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靶点Other Targets
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受体TGase
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研究领域Cancer
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适应症——
化学信息
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CAS Number1025015-40-0
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分子量344.42
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分子式C21H20N4O
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纯度98%
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溶解度DMSO : ≥ 30 mg/mL 87.11 mM
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SMILESC1CCN(C1)CCOc1c(nc2c(n1)cccn2)C#Cc1ccccc1
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化学全称3-(phenylethynyl)-2-(2-(pyrrolidin-1-yl)ethoxy)pyrido[2,3-b]pyrazine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ku BM,et al. Transglutaminase 2 inhibitor abrogates renal cell carcinoma in xenograft models.J Cancer Res Clin Oncol. 2014 May;140(5):757-67.
产品手册
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