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Enprofylline

CAS No. 41078-02-8

Enprofylline ( 3-Propylxanthine | 3-n-Propylxanthine | Enprofyllinum | Enprofilina | 3-propylxanthine | enprofylline )

产品货号. M27397 CAS No. 41078-02-8

恩丙茶碱是一种支气管扩张剂,主要作为竞争性非选择性磷酸二酯酶抑制剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥494 有现货
5MG ¥794 有现货
10MG ¥1142 有现货
25MG ¥2049 有现货
50MG ¥3216 有现货
100MG ¥4763 有现货
500MG ¥10206 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Enprofylline
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    恩丙茶碱是一种支气管扩张剂,主要作为竞争性非选择性磷酸二酯酶抑制剂。
  • 产品描述
    Enprofylline, a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sickle cell disease, diabetic neuropathy, and cerebrovascular insufficiency.
  • 体外实验
    Enprofylline (300 μM) completely blocks the release of IL-8 by N-ethylcarboxamidoadenosine (NECA). Enprofylline (10 μM) inhibits NECA (10 μM) induced proliferation in a concentration-dependent manner. Cell Proliferation Assay Cell Line:Human retinal endothelial cells (HRECs) Concentration:10 μM Incubation Time:24, 48, 72 hours Result:NECA (10 μM) induced a time-dependent increase in HREC proliferation as measured by cell counts, achieving approximately 80% of the density of cells exposed to normal growth medium for 3 days. Enprofylline (10 μM) completely blocked the proliferative effect of NECA when added concurrently with the analogue.
  • 体内实验
    Enprofylline increases heart rate (HR). Injection of Enprofylline (7.5 and 30 mg/kg) increases HR in male WT mouse from 529±23 to 590±20 and 562±20 after the low and high dose, respectively. A high dose of Enprofylline (30 mg/kg) also decreases temperature compared with saline injection in female (but not in males) WT mice, but a low dose (7.5 mg/kg) has little effect on mouse temperature. Animal Model:A1RKO mice (were cross-bred to C57BL/6 mice for six generations) and A2ARKO mice (were backcrossed to C57BL/6 mice for more than 10 generations)Dosage:30 mg/kg Administration:Intraperitoneally injected (bolus) at 2-h intervals Result:Increased HR in male WT mouse from 529±23 to 590±20 and 562±20 after the low (7.5 mg/kg) and high dose (30 mg/kg), respectively.
  • 同义词
    3-Propylxanthine | 3-n-Propylxanthine | Enprofyllinum | Enprofilina | 3-propylxanthine | enprofylline
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Caspase
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    41078-02-8
  • 分子量
    194.19
  • 分子式
    C8H10N4O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 62.5 mg/mL (321.85 mM)
  • SMILES
    CCCN1C2=C(C(=O)NC1=O)NC=N2
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Paunel-G?rgülü A, et al. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216(3):334-342.
产品手册
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