G907 ( G-907;G 907 )

产品货号. M17102 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

G907
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM.
产品描述

G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM; traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket, inhibits the growth of wild-type E. coli and Klebsiella pneumoniae with MIC of 5.6 ug/ml.
同义词

G-907;G 907
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

——
适应症

——

CAS Number

——
分子量

433.93
分子式

C26H24ClNO3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1
化学全称

(E)-3-(6-(1-(2-chloro-6-cyclopropylphenyl)ethoxy)-4-cyclopropylquinolin-3-yl)acrylic acid

1. Ho H, et al. Nature. 2018 May 2. doi: 10.1038/s41586-018-0083-5.

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产品手册

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