G0507 ( G0507 )

产品货号. M10857 CAS No. 1223998-29-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

G0507
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

G 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.
产品描述

G 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity; results in accumulation of fully processed Lpp, an outer membrane lipoprotein, in the inner membrane in E. coli cells, still binds to LolCDE harboring a LolCQ258K mutation, which confers high-level resistance to G0507 in vivo, but no longer stimulates ATPase activity; a useful chemical probe to dissect lipoprotein trafficking in Gram-negative bacteria.
同义词

G0507
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

——
适应症

——

CAS Number

1223998-29-5
分子量

353.40
分子式

C18H15N3O3S
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

5-(4-methoxyphenyl)-6-(5-methylthiophen-2-yl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine-2,4(3H)-dione

1. Nickerson NN, et al. Antimicrob Agents Chemother. 2018 Jan 16. pii: AAC.02151-17.

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