Flubendazole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

氟苯达唑是一种驱虫药，用于治疗人类蠕虫感染。

Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.

Cell Viability AssayCell Line:CRC cells (HCT116, RKO and SW480).Concentration:0-400?μMIncubation Time:48?hResult:Effectively reduces the viability of CRC cells (HCT116, RKO and SW480) in a concentration-dependent manner, with an IC50 of 2-5?μM.Apoptosis Analysis Cell Line:CRC cells (HCT116, RKO and SW480).Concentration:0.3, 0.6, 1.2 μM Incubation Time:48?h Result:Increased the proportion of apoptotic cells in a dose-dependent manner. Dose-dependently effectively increases caspase-3 activity.Cell Autophagy Assay Cell Line:CRC cells (HCT116, RKO and SW480).Concentration:0.3, 0.6, 1.2 μM Incubation Time:24?h Result:Induced autophagy initiation by inactivating mTOR and P62, and upregulating LC3-I/II, which are classical marker of autophagy..Western Blot Analysis Cell Line:CRC cells (HCT116, RKO and SW480).Concentration:0.3, 0.6, 1.2 μM Incubation Time:24?h Result:Strongly reduced the expression of phosphorylated STAT3 (P-STAT3) in a dose and time-dependent manner. No obvious change in total STAT3 expression. Decreased expression of MCL1 and survivin in a dose-dependent manner.

Animal Model:Female BALB/c athymic nude mice (6-8?weeks) with HCT116 cells Dosage:10? or 30?mg/kg Administration:Intraperitoneal injection; every other day; 14 days Result:Markedly reduced the tumor volume. Significantly reduces the protein level of P-STAT3, promotes autophagy and induces apoptosis in vivo.

NSC 313680 | R-17889 | R-17899

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

microtubule

Infection

——

31430-15-6

313.29

C16H12FN3O3

>98% (HPLC)

DMSO: 1 mg/mL (3.19 mM)

O=C(OC)NC1=NC2=CC(C(C3=CC=C(F)C=C3)=O)=CC=C2N1

methyl (5-(4-fluorobenzoyl)-1H-benzo[d]imidazol-2-yl)carbamate

(-20℃)

With Ice Pack

≥ 2 years