Fidaxomicin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Fidaxomicin（OPT-80；PAR-101）是一类新型窄谱大环抗生素化合物。

Fidaxomicin(OPT-80; PAR-101) is a?new class of narrow spectrum macrocyclic antibiotic drug, selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria.Bacterial Infection Approved(In Vitro):Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024?μg/mL).(In Vivo):Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis.

Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024?μg/mL).

Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis. Animal Model:Male Golden Syrian hamsters (80-100 g, Hamster model for pseudomembranous colitis)Dosage:0.2, 1, and 5 mg/kg Administration:Orally, once a day for 5 days, beginning 8 h after infectionResult:Completely prevented the lethality of the animals. Completely prevented the development of antibiotic-induced C. difficile colitis in hamsters at doses as low as 0.2 mg/kg.

OPT-80 | PAR-101

GPCR/G Protein

Antibacterial

RNApolymerase

Infection

Bacterial Infection

873857-62-6

1058.039

C52H74Cl2O18

>98% (HPLC)

DMSO: ≥ 33 mg/mL

O=C(O[C@@H]1[C@@H](C)O[C@@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@H]3[C@@H](O)[C@@H](O)[C@H](OC(C(C)C)=O)C(C)(C)O3)/C(C)=C/C(C)=C/C[C@@H]([C@H](O)C)OC2=O)[C@@H](OC)[C@H]1O)C4=C(O)C(Cl)=C(O)C(Cl)=C4CC

Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1

(-20℃)

With Ice Pack

≥ 2 years