Fesoterodine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Fesoterodine (PF-00695838) 是一种竞争性毒蕈碱受体拮抗剂，具有肌肉松弛和泌尿解痉特性。

Fesoterodine (PF-00695838) is a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties; binds and inhibits muscarinic receptors on the bladder detrusor muscle, prevents bladder contractions or spasms caused by acetylcholine.Other Indication Approved.

Fesoterodine decreases micturition frequency, urgency severity and urgency incontinence episodes and increases the volume voided with each micturition.After oral administration, Fesoterodine is rapidly and extensively hydrolysed in plasma by nonspecific esterases to Desfesoterodine (5-hydroxymethyl tolterodine; SPM 7605; HY-76569; an active metabolite of Fesoterodine).

Fesoterodine (0.01-1 mg/kg; IV) reduces the micturition pressure and increases bladder capacity and ICIs (intercontraction intervas) at the lowest dose tested of 0.01 mg/kg. Animal Model:Bladders from female Sprague-Dawley rats (225-275 g)Dosage:0.01, 0.1 and 1 mg/kg Administration:IV Result:Reduced the micturition pressure and increased bladder capacity and ICIs at the lowest dose tested of 0.01 mg/kg.

PF-00695838

GPCR/G Protein

mAChR

mAChR

Other Indications

Other Disease

286930-02-7

411.278

C26H37NO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (242.97 mM)

CC(C)C(=O)OC1=C(C=C(C=C1)CO)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2

[2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate

(-20℃)

With Ice Pack

≥ 2 years