FT-001 ( FT001 )

产品货号. M12678 CAS No. 1778655-51-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

FT-001
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

FT-001 is a novel potent, orally acitve inhibitor of BET bromodomain with IC50 of 0.1 uM for BRD4 BD1.
产品描述

FT-001 is a novel potent, orally acitve inhibitor of BET bromodomain with IC50 of 0.1 uM for BRD4 BD1; inhibits the expression of MYC in the MV-4-11 cell line with IC50 of 0.46 uM, shows anti-proliferative activity with IC50 of 0.22 uM; displays complete tumor growth inhibition in mouse MV-4-11 xenograft model.
同义词

FT001
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1778655-51-8
分子量

467.58
分子式

C25H29N3O4S
纯度

>98% (HPLC)
溶解度

——
SMILES

CC(N1[C@@H](C)CN(C(C2CC2)=O)C3=C1C=CC(C4=CC=C(N(CC5)CCS5(=O)=O)C=C4)=C3)=O
化学全称

(S)-1-(4-(cyclopropanecarbonyl)-6-(4-(1,1-dioxidothiomorpholino)phenyl)-2-methyl-3,4-dihydroquinoxalin-1(2H)-yl)ethan-1-one

1. Millan DS, et al. ACS Med Chem Lett. 2017 Jul 14;8(8):847-852.

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产品手册

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