
FR054
CAS No. 35954-65-5
FR054 ( —— )
产品货号. M28708 CAS No. 35954-65-5
FR054是己糖胺生物合成途径(HBP)酶PGM3的抑制剂,具有显着的抗乳腺癌作用。 FR054 会导致不同乳腺癌细胞的细胞增殖和存活率急剧下降。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥316 | 有现货 |
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10MG | ¥478 | 有现货 |
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25MG | ¥761 | 有现货 |
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50MG | ¥1037 | 有现货 |
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100MG | ¥1604 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称FR054
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述FR054是己糖胺生物合成途径(HBP)酶PGM3的抑制剂,具有显着的抗乳腺癌作用。 FR054 会导致不同乳腺癌细胞的细胞增殖和存活率急剧下降。
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产品描述FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival.(In Vivo):The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects. FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. FR054 (250?μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells. FR054 induces endoplasmic reticulum stress and ROS-dependent apoptotic cell death .
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体外实验Cell Viability Assay Cell Line:MDA-MB-231 cells.Concentration:0.5-1?mM.Incubation Time:48 h.Result:Reduced viability and a significant increase of the apoptosis as compared to the control clone.
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体内实验Animal Model:Mice were subcutaneously injected with MDA-MB-231 cells.Dosage:1000?mg/kg.Administration:IP, single or fractionated dose (twice a day 500?mg/kg/dose).Result:Appears to have an in vivo antitumor efficacy that is higher when administered twice a day compared to single administration.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number35954-65-5
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分子量657.6
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分子式C28H37N2O16
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (303.67 mM)
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SMILESCC(OC[C@H]([C@H]1OC(C)=O)O[C@@H]2OC(C)=N[C@@H]2[C@H]1OC(C)=O)=OCC(OC[C@H]([C@H]1OC(C)=O)O[C@@H]2OC(C)=N[C@@H]2[C@H]1OC(C)=O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Mukhopadhyay S., Chandalia S.B. Oxidative Chlorination, desulphonation, or decarboxylation to synthesize pharmaceutical intermediates: 2,6-Dichlorotoluene, 2,6-dichloroaniline, and 2,6-dichlorophenol. Org. Process Res. Dev. 1999;3:10–16.
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