A-196 ( SGC A-196 | SGC A 196 | SGC A196 )

产品货号. M17412 CAS No. 1982372-88-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

A-196
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A-196 是 SUV420 h1 和 SUV420 h2 的有效选择性抑制剂，IC50 值分别为 0.025 和 0.144 μM。
产品描述

SGC A-196 is a potent inhibitor of SUV420H1 (IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM), a closely related pair of proteins which catalyze the di- and tri-methylation of H4K20.
体外实验

Western Blot Analysis Cell Line:U2OS cells Concentration:0 μM, 0.075 μM, 0.15 μM, 0.3 μM, 0.6 μM, 1.25 μM, 2.5 μM, 5 μM Incubation Time:48 hours Result:Increased in H4K20me1 and decreased in both H4K20me2 and H4K20me3.
体内实验

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同义词

SGC A-196 | SGC A 196 | SGC A196
通路

Others
靶点

Other Targets
受体

SUV420H1|SUV420H2
研究领域

Cancer
适应症

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1.Bromberg KD,etal.The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.Nat Chem Biol. 2017 Mar;13(3):317-324.

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