FGH-10019 ( —— )

产品货号. M21072 CAS No. 1046045-61-7

FGH-10019 是一种新型甾醇调节元件结合蛋白 (SREBP) 抑制剂 (IC50:1 μM)。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥2195	有现货
10MG	￥3183	有现货
25MG	￥5330	有现货
50MG	￥7590	有现货
100MG	￥10287	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

FGH-10019
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

FGH-10019 是一种新型甾醇调节元件结合蛋白 (SREBP) 抑制剂 (IC50:1 μM)。
产品描述

FGH-10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).
体外实验

Treatment of the CHO-K1 cells with analog FGH10019 decreases the percentage of the mature form of SREBP-2 (68 kDa) at lower concentrations than treatment with fatostatin. Densitometric analysis of the gels indicates that the IC50 of analog FGH10019 is approximately 1 μM, which is 5-10 times lower than the IC50 of fatostatin (appr 10 μM).
体内实验

FGH10019-treated chow is fed at a dose rate calculated to provide about 0.7 mg analog FGH10019 per day, at about 23 mg/kg body weight, to 5-wk-old male ob/ob mice weighing an average of appr 30 g. After 8 wk on the analog 24-treated chow, the mice gain 8-9 % less weight than control mice.
同义词

——
通路

Others
靶点

Other Targets
受体

SREBPs
研究领域

——
适应症

——

化学信息

CAS Number

1046045-61-7
分子量

373.49
分子式

C18H19N3O2S2
纯度

>98% (HPLC)
溶解度

DMSO:38 mg/mL (101.74 mM)
SMILES

CCCc1cc(-c2nc(-c3ccc(NS(C)(=O)=O)cc3)cs2)ccn1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Kamisuki S Shirakawa T Kugimiya A et al. Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins[J]. Journal of Medicinal Chemistry 2011 54(13):4923-4927.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册