
MS37452
CAS No. 423748-02-1
MS37452 ( —— )
产品货号. M27460 CAS No. 423748-02-1
MS37452 是 CBX7 染色结构域与 H3K27me3 结合的竞争性抑制剂 (Ki = 43 μM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥381 | 有现货 |
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10MG | ¥648 | 有现货 |
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25MG | ¥1442 | 有现货 |
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50MG | ¥2608 | 有现货 |
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100MG | ¥4496 | 有现货 |
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500MG | ¥9558 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称MS37452
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述MS37452 是 CBX7 染色结构域与 H3K27me3 结合的竞争性抑制剂 (Ki = 43 μM)。
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产品描述MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 μM).
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体外实验MS37452 (125-500 μM; 12 hours) significantly increases INK4A/ARF transcript levels up to 25% and 60% for 250 μM and 500 μM, respectively, as compared to the DMSO control.MS37452 (250 μM; 2 hours) treats human PC3 prostate cancer cells for 2 hours reducing CBX7 occupancy across the INK4A/ARF locus.MS37452 (200 μM; 5 days) combined with doxorubicin results in consistently decreased cell viability compared to DMSO treated and single drug treatment.MS37452 (200 μM; 5 days), which is a CBX7 chromodomain inhibitor (CBX7i), in combination with doxorubicin is a novel therapeutic strategy. RT-PCR Cell Line:PC3 cells Concentration:125-500 μM Incubation Time:12 hours Result:Up-regulated INK4A/ARF expression up to 25% and 60% for 250 μM and 500 μM, respectively.Cell Viability Assay Cell Line:Glioblastoma multiforme (GBM) U118MG cells Concentration: PRT4165 40 μM, PTC209 200 nM, DZnep 25 μM, GSK343 400 nM, MS37452 200 μM, Doxorubicin 200 nM, temozolomide 50 μM, SAHA 1 μM Incubation Time:5 days Result:Identified several combinations that resulted in consistently decreased cell viability compared to DMSO treated and single drug treatment: SAHA/TMZ and MS37452/doxorubicin.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Parasite|MmpL3
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研究领域——
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适应症——
化学信息
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CAS Number423748-02-1
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分子量398.459
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分子式C22H26N2O5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (250.97 mM)
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SMILESCOc1cccc(C(=O)N2CCN(CC2)C(=O)COc2cccc(C)c2)c1OC
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Veiga-Santos P, et al. SQ109, a new drug lead for Chagas disease. Antimicrob Agents Chemother. 2015 Apr;59(4):1950-61.
产品手册




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