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FCCP

CAS No. 370-86-5

FCCP ( Trifluoromethoxy carbonylcyanide phenylhydrazone )

产品货号. M14275 CAS No. 370-86-5

FCCP 是线粒体氧化磷酸化的有效解偶联剂,可通过跨细胞膜运输质子来破坏 ATP 合成。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥292 有现货
10MG ¥413 有现货
25MG ¥745 有现货
50MG ¥1345 有现货
100MG ¥2511 有现货
200MG ¥4196 有现货
500MG ¥6707 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    FCCP
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    FCCP 是线粒体氧化磷酸化的有效解偶联剂,可通过跨细胞膜运输质子来破坏 ATP 合成。
  • 产品描述
    FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.(In Vitro):FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability in K695sw cells. FCCP (5 μM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells. FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    Trifluoromethoxy carbonylcyanide phenylhydrazone
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    370-86-5
  • 分子量
    254.17
  • 分子式
    C10H5F3N4O
  • 纯度
    >98% (HPLC)
  • 溶解度
    Ethanol: 50 mg/mL (196.71 mM) DMSO: 50 mg/mL (196.71 mM) Water: <1 mg/mL
  • SMILES
    N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1
  • 化学全称
    N-(4-(trifluoromethoxy)phenyl)carbonohydrazonoyl dicyanide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.HEYTLER PG et al. A new class of uncoupling agents--carbonyl cyanide phenylhydrazones. Biochem Biophys Res Commun. 1962 May 4;7:272-5.
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