Exisulind
CAS No. 59973-80-7
Exisulind ( Sulindac sulfone; CP248 )
产品货号. M27766 CAS No. 59973-80-7
Exisulind induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥381 | 有现货 |
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10MG | ¥648 | 有现货 |
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25MG | ¥1320 | 有现货 |
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50MG | ¥1968 | 有现货 |
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100MG | ¥2908 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Exisulind
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Exisulind induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.
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产品描述Exisulind induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.(In Vivo):The topical treatment with NO-Exisulind significantly reduced UVB-induced tumors in SKH-1 hairless mice. The tumors/tumor bearing mouse, the number of tumors/mouse and tumor volume/mouse decreased significantly (P < 0.05) as compared with vehicle-treated and UVB-irradiated positive controls. NO-Exisulind-treated animals showed reduced expression of proliferation markers, such as PCNA and cyclin D1. These mice also manifested increased expression of proapoptotic Bax and decreased expression of antiapoptotic Bcl2 with an increase in the number of TUNEL-positive cells in tumors. NO-Exisulind-treated tumors are less invasive and progress less efficiently from benign to malignant carcinomas.
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同义词Sulindac sulfone; CP248
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通路Apoptosis
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靶点Apoptosis
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number59973-80-7
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分子量372.4
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分子式C20H17FO4S
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccc(cc1)S(C)(=O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Simon L Hill, et al. Clinical toxicology of newer recreational drugs. Clin Toxicol (Phila). 2011 Oct;49(8):705-19.
产品手册
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