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Etofibrate

CAS No. 31637-97-5

Etofibrate ( Nicotinic Acid )

产品货号. M14031 CAS No. 31637-97-5

依托贝特是氯贝特和烟酸的组合,用于治疗高脂血症。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
10MG ¥324 有现货
25MG ¥527 有现货
50MG ¥689 有现货
100MG ¥1053 有现货
200MG ¥1604 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Etofibrate
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    依托贝特是氯贝特和烟酸的组合,用于治疗高脂血症。
  • 产品描述
    Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.(In Vivo):Etofibrate is the ethandiol-1,2 diester of the nicotinic and clofibric acids. Etofibrate has been shown to be a potent hypolipidemic agent in animal and human. After 10 days of treatment with Etofibrate, the rats show a body weight similar to that found in the control animals but their liver weight is significantly enhanced whereas plasma cholesterol and triacylglycerol levels are decreased. Etofibrate treatment increases the bile flow of the animals, the effect being especially manifest during the first 2 hr after interruption of the enterohepatic circulation and the difference with the controls becomes statistically significant at 30 and 90 min. The cumulative amount of bile secreted plotted against time shows a highly significant linear correlation for both control and Etofibrate treated rats, the slope being significantly higher for the Etofibrate group than for controls.
  • 体外实验
    ——
  • 体内实验
    Etofibrate is the ethandiol-1,2 diester of the nicotinic and clofibric acids. Etofibrate has been shown to be a potent hypolipidemic agent in animal and human. After 10 days of treatment with Etofibrate, the rats show a body weight similar to that found in the control animals but their liver weight is significantly enhanced whereas plasma cholesterol and triacylglycerol levels are decreased. Etofibrate treatment increases the bile flow of the animals, the effect being especially manifest during the first 2 hr after interruption of the enterohepatic circulation and the difference with the controls becomes statistically significant at 30 and 90 min. The cumulative amount of bile secreted plotted against time shows a highly significant linear correlation for both control and Etofibrate treated rats, the slope being significantly higher for the Etofibrate group than for controls.
  • 同义词
    Nicotinic Acid
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Other Indications
  • 适应症
    ——

化学信息

  • CAS Number
    31637-97-5
  • 分子量
    363.79
  • 分子式
    C18H18ClNO5
  • 纯度
    >98% (HPLC)
  • 溶解度
    Ethanol: 73 mg/mL (200.66 mM); DMSO: 73 mg/mL (200.66 mM)
  • SMILES
    O=C(C1=CC=CN=C1)OCCOC(C(C)(OC2=CC=C(Cl)C=C2)C)=O
  • 化学全称
    2-[2-(4-Chlorophenoxy)-2-methylpropanoyl]oxyethyl pyridine-3-carboxylate

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Herrera E, et al. Biochim Biophys Acta, 1988, 963(1), 42-52.
产品手册
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