Etiocholanone ( —— )

产品货号. M24515 CAS No. 53-42-9

Etiocholanolone (5β-Androsterone) 是睾酮的排泄代谢产物，具有抗惊厥活性。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥441	有现货
5MG	￥538	有现货
10MG	￥811	有现货
25MG	￥1464	有现货
50MG	￥2205	有现货
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Etiocholanone
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Etiocholanolone (5β-Androsterone) 是睾酮的排泄代谢产物，具有抗惊厥活性。
产品描述

Etiocholanolone (5β-Androsterone) is the excreted?metabolite?of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent?neurosteroid positive allosteric modulator?(PAM) of the?GABAA?receptor than its?enantiomer form.
体外实验

Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it isineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect).
体内实验

Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50?values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice.
同义词

——
通路

Membrane Transporter/Ion Channel
靶点

Other Targets
受体

GABAA
研究领域

——
适应症

——

化学信息

CAS Number

53-42-9
分子量

290.44
分子式

C19H30O2
纯度

>98% (HPLC)
溶解度

DMSO:97 mg/mL?(333.97 mM;?Need ultrasonic)
SMILES

C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@H]3C[C@@H]1O)C2=O
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Ping Li,et al. Natural and Enantiomeric Etiocholanolone Interact With Distinct Sites on the Rat alpha1beta2gamma2L GABAA Receptor. Mol Pharmacol. 2007 Jun;71(6):1582-90.

计算器

浓度计算器

摩尔计算器

分子量计算器

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