Lyciumamide B is a natural product for research related to life sciences.

Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). Shown to protect pancreatic acinar cells from gossypol induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.

ML221 是一种有效的 apelin /APJ 功能拮抗剂，抑制 apelin-13 介导的 APJ 激活，cAMP 测定中的 IC50 为 0.70 μM，β-arrestin 测定中的 IC50 为 1.75 μM，两种测定中的 EC80 均为 10 nM。