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Eribaxaban
CAS No. 536748-46-6
Eribaxaban ( PD-0348292 | PD0348292 | PD 0348292 )
产品货号. M14904 CAS No. 536748-46-6
一种有效的、选择性的、口服有效的 Xa 因子 (FXa) 抑制剂，IC50 为 0.32 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
|
| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Eribaxaban
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的、选择性的、口服有效的 Xa 因子 (FXa) 抑制剂，IC50 为 0.32 nM。
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产品描述A potent, selective and orally efficacious factor Xa (FXa) inhibitor with IC50 of 0.32 nM; displays >1,000-fold selectivity over a series of related serine proteases (thrombin, activated protein C, plasmin, tissue plasminogen activator and trypsin); potently inhibits thrombosis and shows potential for s for the treatment and prevention of thrombotic disorders.Thrombosis Phase 2 Discontinued.
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体外实验——
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体内实验——
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同义词PD-0348292 | PD0348292 | PD 0348292
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通路Metabolic Enzyme/Protease
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靶点Factor Xa
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受体Factor Xa
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研究领域Cardiovascular Disease
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适应症Thrombosis
化学信息
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CAS Number536748-46-6
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分子量484.912
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分子式C24H22ClFN4O4
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(NC1=CC=C(Cl)C=C1)N2C[C@@H](C[C@H]2C(NC3=CC=C(N4C=CC=CC4=O)C=C3F)=O)OC
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化学全称(2R,4R)-1-N-(4-chlorophenyl)-2-N-[2-fluoro-4-(2-oxopyridin-1-yl)phenyl]-4-methoxypyrrolidine-1,2-dicarboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kohrt JT, et al. Chem Biol Drug Des. 2007 Aug;70(2):100-12.
2. McBane RD 2nd, et al. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):413-8.
3. Karnicki K, et al. Thromb Haemost. 2008 Apr;99(4):759-66.
4. Cohen AT, et al. J Thromb Haemost. 2013 Aug;11(8):1503-10.
产品手册
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