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Entinostat
CAS No. 209783-80-2
Entinostat ( MS-275;SNDX-275;MS 275;SNDX 275 )
产品货号. M13310 CAS No. 209783-80-2
A potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥405 | 有现货 |
|
| 25MG | ￥583 | 有现货 |
|
| 50MG | ￥729 | 有现货 |
|
| 100MG | ￥1021 | 有现货 |
|
| 200MG | ￥1563 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Entinostat
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3.
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产品描述A potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3; no inhibition on HDAC8/4/5/7/9/6/10 (IC50>10 uM); induces accumulation of p21WAF1/CIP1 and gelsolin in K562 cell; reduce S-phase cells and induce G1-phase cells in A2780 cell.Breast Cancer Phase 3 Clinical
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同义词MS-275;SNDX-275;MS 275;SNDX 275
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC1;HDAC3
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研究领域Cancer
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适应症Breast Cancer
化学信息
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CAS Number209783-80-2
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分子量376.41
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分子式C21H20N4O3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(OCC1=CC=CN=C1)NCC2=CC=C(C(NC3=CC=CC=C3N)=O)C=C2
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化学全称Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Saito A, et al. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4592-7.
2. Lauffer BE, et al. J Biol Chem. 2013 Sep 13;288(37):26926-43.
3. Rosato RR, et al. Cancer Res, 2003, 63(13), 3637-3645.
2. Lauffer BE, et al. J Biol Chem. 2013 Sep 13;288(37):26926-43.
3. Rosato RR, et al. Cancer Res, 2003, 63(13), 3637-3645.
产品手册
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