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EDO-S101
CAS No. 1236199-60-2
EDO-S101 ( EDO-S 101;Tinostamustine )
产品货号. M10949 CAS No. 1236199-60-2
EDO-S101 (Tinostamustine)is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥437 | 有现货 |
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| 5MG | ￥624 | 有现货 |
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| 10MG | ￥1021 | 有现货 |
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| 25MG | ￥1677 | 有现货 |
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| 50MG | ￥2989 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称EDO-S101
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述EDO-S101 (Tinostamustine)is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat.
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产品描述EDO-S101 (Tinostamustine)is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat; displays potent activity in vitro in MM cell lines (IC50=1.6-4.8 uM) and ex vivo in cells isolated from MM patients; shows activity in CB17-SCID murine plasmacytoma model and in de novo Vk*MYC mice, also is the only drug with single-agent activity in the multidrug resistant Vk12653 murine model.Blood Cancer Phase 1 Clinical
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同义词EDO-S 101;Tinostamustine
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC1;HDAC2;HDAC3;HDAC6;HDAC8
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number1236199-60-2
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分子量415.36
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分子式C19H28Cl2N4O2
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 30 mg/mL
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SMILESCN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCCCCC(=O)NO
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化学全称1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mehrling T, et al. Anticancer Agents Med Chem. 2016;16(1):20-8.
2. López-Iglesias AA, et al. J Hematol Oncol. 2017 Jun 20;10(1):127.
3. Besse L, et al. Blood Cancer J. 2017 Jul 28;7(7):e589.
2. López-Iglesias AA, et al. J Hematol Oncol. 2017 Jun 20;10(1):127.
3. Besse L, et al. Blood Cancer J. 2017 Jul 28;7(7):e589.
产品手册
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