EB1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

EB1 是 MNK 激酶的抑制剂，IC50 分别为 0.69 μM (MNK1) 和 9.4 μM (MNK2)。EB1 选择性地抑制癌细胞的生长，不抑制正常细胞的生长。EB1 还增加细胞凋亡，抑制 eIF4E 磷酸化。

EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation.

Western Blot Analysis Cell Line:MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells Concentration:1.3 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time:24 hours Result:Blocked the phosphorylation of eIF4E in a dose-dependent manner.Apoptosis Analysis Cell Line:MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells Concentration:2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time:72 hours Result:Increased the percentage of apoptosis cells among tumor cells.

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MAPK/ERK Signaling

MNK

MNK

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42951-68-8

286.33

C18H14N4

>98% (HPLC)

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NC=1C2=C(C=C(N=C2NN1)C3=CC=CC=C3)C4=CC=CC=C4

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(-20℃)

With Ice Pack

≥ 2 years