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Droxinostat
CAS No. 99873-43-5
Droxinostat ( NS 41080;NS-41080;NS41080 )
产品货号. M16918 CAS No. 99873-43-5
Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥251 | 有现货 |
|
| 5MG | ￥373 | 有现货 |
|
| 10MG | ￥705 | 有现货 |
|
| 25MG | ￥1499 | 有现货 |
|
| 50MG | ￥2252 | 有现货 |
|
| 100MG | ￥3345 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Droxinostat
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively.
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产品描述Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively; does not inhibit HDAC1, HDAC2, HDAC4, HDAC5, HDAC7, HDAC9, and HDAC10 with IC50 of >20 uM; sensitizes malignant cells to death receptor ligands FAS and TRAIL sensitization with IC50 of 20 and 39 uM, respectively; decreases the expression of the caspase-8 inhibitor FLIP, downregulates c-FLIP(L) and c-FLIP(S) mRNA and protein levels, causes PARP degradation, reduces cell survival, and induces apoptosis in MCF-7 breast cancer cells.
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同义词NS 41080;NS-41080;NS41080
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC10;HDAC3;HDAC6;HDAC8;HDAC9
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研究领域Cancer
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适应症——
化学信息
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CAS Number99873-43-5
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分子量243.70
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分子式C11H14ClNO3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(NO)CCCOC1=CC=C(Cl)C=C1C
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化学全称Butanamide, 4-(4-chloro-2-methylphenoxy)-N-hydroxy-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wood TE, et al. Mol Cancer Ther. 2010 Jan;9(1):246-56.
2. Bijangi-Vishehsaraei K, et al. Mol Cell Biochem. 2010 Sep;342(1-2):133-142.
3. McCourt C, et al. Clin Cancer Res. 2012 Jul 15;18(14):3822-33.
4. Liu J, et al. Transl Oncol. 2016 Feb;9(1):70-78.
2. Bijangi-Vishehsaraei K, et al. Mol Cell Biochem. 2010 Sep;342(1-2):133-142.
3. McCourt C, et al. Clin Cancer Res. 2012 Jul 15;18(14):3822-33.
4. Liu J, et al. Transl Oncol. 2016 Feb;9(1):70-78.
产品手册
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