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Dooku1
CAS No. 2253744-54-4
Dooku1 ( —— )
产品货号. M26169 CAS No. 2253744-54-4
Dooku1 是 Yoda1 的类似物，也是内源性 Piezo1 通道的选择性拮抗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥437 | 有现货 |
|
| 5MG | ￥721 | 有现货 |
|
| 10MG | ￥1158 | 有现货 |
|
| 25MG | ￥2333 | 有现货 |
|
| 50MG | ￥4342 | 有现货 |
|
| 100MG | ￥6261 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Dooku1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Dooku1 是 Yoda1 的类似物，也是内源性 Piezo1 通道的选择性拮抗剂。
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产品描述Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yoda1-induced aortic relaxation.
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体外实验Cell Viability Assay Cell Line:HUVECs, Piezo1 T-REx cells Concentration:10 μM Incubation Time:40-60 s Result:Had a concentration-dependent inhibitory effect against Yoda1-induced Ca2+ entry in HUVECs, acting with an IC50 of 1.49 μM.Increased potency in HUVECs with an EC50 of 0.23 μM, compared with 2.51 μM in Piezo1 T-REx cells.
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体内实验Animal Model:wild-type male C57BL/6 mice’s aortic rings Dosage:10 μM Administration:20 min Result:Suppressed the Yoda1-induced relaxation.
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同义词——
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通路Others
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靶点Other Targets
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受体Bacterial
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研究领域——
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适应症——
化学信息
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CAS Number2253744-54-4
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分子量326.2
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分子式C13H9Cl2N3OS
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (306.56 mM)
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SMILESClc1cccc(Cl)c1CSc1nnc(o1)-c1ccc[nH]1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Alois Pískala, et al. Synthesis, molecular conformation and biological activity of 6-amino-5-azacytidine. Collect. Czech. Chem. Commun. 1989, 54, 2502-2512.
产品手册
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