
JNK-IN-7
CAS No. 1408064-71-0
JNK-IN-7 ( JNK-IN-7 | JNK inhibitor | JNKIN7 | JNK IN 7 )
产品货号. M17280 CAS No. 1408064-71-0
JNK-IN-7 是一种选择性 JNK1/2/3 抑制剂 (IC50: 1.54/1.99/0.75 nM)。它还可以抑制 c-Jun 的磷酸化,c-Jun 是 JNK 激酶的底物。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1304 | 有现货 |
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5MG | ¥1928 | 有现货 |
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10MG | ¥2479 | 有现货 |
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25MG | ¥4455 | 有现货 |
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50MG | ¥6415 | 有现货 |
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100MG | ¥8748 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称JNK-IN-7
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述JNK-IN-7 是一种选择性 JNK1/2/3 抑制剂 (IC50: 1.54/1.99/0.75 nM)。它还可以抑制 c-Jun 的磷酸化,c-Jun 是 JNK 激酶的底物。
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产品描述JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C.(In Vitro):JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function.
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体外实验JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function.
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体内实验——
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同义词JNK-IN-7 | JNK inhibitor | JNKIN7 | JNK IN 7
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通路Others
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靶点Other Targets
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受体JNK1| JNK2| JNK3
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number1408064-71-0
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分子量493.56
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分子式C28H27N7O2
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纯度>98% (HPLC)
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溶解度DMSO : 33.33 mg/mL. 67.53 mM; H2O : < 0.1 mg/mL
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SMILESC(=O)(Nc1cccc(c1)C(=O)Nc1ccc(cc1)Nc1nccc(n1)c1cnccc1)/C=C/CN(C)C
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化学全称3-[[(E)-4-(Dimethylamino)but-2-enoyl]amino]-N-[4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Zhang T, et al. Chem Biol, 2012, 19(1): 140-154.
产品手册




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