Dipraglurant

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dipraglurant (ADX48621) 是一种有效的，选择性的，具有口服活性和可透过血脑屏障的 mGluR5 的负变构调节剂 (NAM)，IC50 值为 21 nM。Dipraglurant 可以减少左旋多巴诱发的运动障碍 (LID)。

Dipraglurant (ADX48621) is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo. Dipraglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Dipraglurant (1-10 μM; 15 min) counteracts the abnormal membrane responses and calcium rise induced either by the D2R agonist quinpirole or by caged dopamine (NPEC-Dopamine).

Dipraglurant (3-30 mg/kg; a single p.o.) reduces L-dopa-induced chorea and dystonia and does not interfere with the ef?cacy of L-dopa in treating parkinsonian disability macaque.Dipraglurant exhibits Cmax (1.040, 1.380, 5.310 ng/mL) Tmax (1.0, 0.5, 1.0 h) and AUCinf (2.230, 2.860, 15.700) following p.o. administration (3, 10, 30 mg/kg) in macaque.

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Neuroscience

GluR

GluR

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872363-17-2

265.29

C16H12FN3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 40 mg/mL (150.78 mM )

Fc1ccc2nc(CCC#Cc3ccccn3)cn2c1

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(-20℃)

With Ice Pack

≥ 2 years