Diflapolin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Diflapolin 是一种高活性的 5-脂氧合酶激活蛋白 (FLAP)/可溶性环氧化物水解酶 (sEH) 双重抑制剂，具有显着的抗炎功效和高靶点选择性。

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.

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Diflapolin (1-10 mg/kg; i.p.; 30?min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments. Animal Model:Male CD-1 mice (zymosan-induced peritonitis mouse model)Dosage:1, 3 and 10?mg/kg Administration:I.p.; 30?min before zymosan injection Result:Induced a significant reduction of LTC4 and LTB4 peritoneal levels, starting from the dose of 1?mg/kg and comparable to the effect of MK886.

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Immunology/Inflammation

FLAP

sHE|FLAP

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724453-98-9

458.4

C22H17Cl2N3O2S

>98% (HPLC)

DMSO:84mg/mL (183.26mM)

O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C(OCC3=NC4=CC=CC=C4S3)C=C2C

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(-20℃)

With Ice Pack

≥ 2 years