Diciofenac

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

双氯芬酸是一种非甾体类抗炎药 (NSAID)，用于减轻炎症并在某些情况下作为镇痛药减轻疼痛。它以多种商品名作为药物提供或包含在药物中。

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. It is supplied as or contained in medications under a variety of trade names.(In Vitro):Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7±3 nM.Diclofenac (1-60 μM; 1 day) induces neural stem cells (NSCs)death in a concentration-dependent manner.Diclofenac (10-60 μM; 6 hours) increases the expression of cleaved (activated) caspase-3.(In Vivo):Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days.Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats.

Cell Viability Assay Cell Line:Neural stem cells (NSCs)Concentration:1, 3, 10, 30, 60 μM Incubation Time:1 day Result:Induction of cell death was concentration-dependent and the effect was not saturated at a concentration of up to 60 μM.Western Blot Analysis Cell Line:Neural stem cells (NSCs)Concentration:10, 30 or 60 μM Incubation Time:6 hours Result:The activation of caspase-3 was increased in a concentration-dependent manner.

Animal Model:Male Sprague-Dawley rats (150±200 g)Dosage:3 mg/kg Administration:Oral administration, b.i.d., for 5 days Result:Resulted in a significant increase in faecal 51Cr excretion.Animal Model:Wistar rats (150-175 g) bearing Formalin-induced rat foot paw edema model Dosage:10 mg/kg Administration:Administered via oral route just prior to induction of inflammation Result:Showed in vivo anti-inflammatory activity (% edema inhibition=29.2, 1 h; 22.2, 3 h; 20, 6 h).

——

Chromatin/Epigenetic

COX

COX

Inflammation/Immunology

——

15307-86-5

296.15

C14H11Cl2NO2

>98% (HPLC)

Water: 2.37 mg/L

C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl

——

(-20℃)

With Ice Pack

≥ 2 years