DiMNF

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DiMNF (3',4'-Dimethoxy-αNF) 是一种选择性芳基烃受体 (AHR) 调节剂。 DiMNF 是一种具有明显拮抗活性的竞争性 AHR 配体 (IC50 = 21 nM)。 DiMNF 可用作抗炎剂。

DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent.

DiMNF (3',4'-Dimethoxy-αNF) (10 μM; 4 h) minimally influences AHR gene battery.DiMNF (10 μM; 1 h) effectively suppresses cytokine-mediated inflammatory gene expression.DiMNF adopts a unique orientation within the ligand binding pocket of AHR.RT-PCR Cell Line:Huh7 cell Concentration:10 μM Incubation Time:4 h or 1 h Result:Decreased CYP1A1 mRNA expression (4 h). Exhibited repressive activity toward cytokine-mediated SAA1 induction (1 h). Significantly reduced IL1β-mediated mRNA induction of C4, C1S, C1R, and C3.

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Others

Other Targets

Others

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14756-24-2

332.35

C21H16O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 12.5 mg/mL (37.61 mM; 超声助溶 (<70°C)

COc1ccc(cc1OC)-c1cc(=O)c2ccc3ccccc3c2o1

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(-20℃)

With Ice Pack

≥ 2 years