Dehydrocrenatidine ( 去氢苦木碱 )

产品货号. M39685 CAS No. 65236-62-6

Dehydrocrenatidine 是天然的生物碱，是特异性的 JAK 抑制剂。Dehydrocrenatidine在大鼠神经痛模型中抑制电压门控钠通道并改善机械性异位。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
25MG	获取报价	有现货
50MG	获取报价	有现货
100MG	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Dehydrocrenatidine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Dehydrocrenatidine 是天然的生物碱，是特异性的 JAK 抑制剂。Dehydrocrenatidine在大鼠神经痛模型中抑制电压门控钠通道并改善机械性异位。
产品描述

Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain.
体外实验

Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations.Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation.DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 μM and 4.87 μM, respectively.
体内实验

Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations.Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation.DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 μM and 4.87 μM, respectively.
同义词

去氢苦木碱
通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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